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dc.contributor.authorVarol, Mehmet
dc.date.accessioned2020-07-09T20:58:55Z
dc.date.available2020-07-09T20:58:55Z
dc.date.issued2019
dc.identifier.issn0102-695X
dc.identifier.urihttps://doi.org/10.1016/j.bjp.2019.04.012
dc.identifier.urihttps://hdl.handle.net/11421/24099
dc.descriptionWOS: 000503861400006en_US
dc.description.abstractLichens that are exclusive symbiotic organisms composed of fungus and alga, are considered as a wealthy source of biologically and pharmacologically active small-molecules thanks to the tight metabolic relationship between symbiotic partners. We herein report cytotoxic, anti-angiogenic and apoptotic profile of a lichen derived small-molecule named parietin. Parietin was isolated from the acetone extract of Xanthoria parietina (L.) Th.Fr (1860), Teloschistaceae, which was gathered from Afyon, Turkey. AlamarBlue (TM) cell viability, lactate dehydrogenase membrane leakage and PicoGreen (TM) dsDNAquantitation assays were used to determine the cytotoxic concentrations of parietin on cisplatin-resistant BRCA2-mutated human breast TNM stage IV adenocarcinoma (HCC1428), human breast ductal carcinoma (T-47D), and human umbilical vein endothelial (HUVEC) cells. Additionally, cell adhesion, endothelial tube formation, reactive oxygen species accumulation and active caspase 3 determination assays were employed to identify the anti-angiogenic and apoptotic efficiency of parietin. Low concentrations of parietin such as 50 and 100 mu M showed a significant anti-angiogenic and apoptotic activity though the half-maximal inhibitory concentration (IC50) values were higher than 600 mu M on the cells. on the other hand, it was observed that parietin shows less cytotoxic and membrane degradative activities on healthy HUVEC cells than the HCC1428 and T-47D breast cancer cells. Parietin seems to be a promising anti-angiogenic and apoptotic lichen metabolite for the further investigations. (C) 2019 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda.en_US
dc.description.sponsorshipCommission of Scientific Research Projects of Anadolu UniversityAnadolu University [1502F068]en_US
dc.description.sponsorshipI thank Prof. Ayse Tansu Koparal, Prof. Aysen Turk, Assoc. Prof. Mehmet Candan, Assoc. Prof..Ilker Avan and Aysegul Varol, PhD(c). from Anadolu University, Turkey for their contributions and supports, and the Commission of Scientific Research Projects of Anadolu University for the financial supports of the related project (grant number: 1502F068).en_US
dc.language.isoengen_US
dc.publisherSoc Brasileira Farmacognosiaen_US
dc.relation.isversionof10.1016/j.bjp.2019.04.012en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectApoptosisen_US
dc.subjectCaspaseen_US
dc.subjectLichenen_US
dc.subjectNatural productsen_US
dc.subjectParietinen_US
dc.titleParietin as an efficient and promising anti-angiogenic and apoptotic small-molecule from Xanthoria parietinaen_US
dc.typearticleen_US
dc.relation.journalRevista Brasileira De Farmacognosia-Brazilian Journal of Pharmacognosyen_US
dc.contributor.departmentAnadolu Üniversitesien_US
dc.identifier.volume29en_US
dc.identifier.issue6en_US
dc.identifier.startpage728en_US
dc.identifier.endpage734en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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