The antinociceptive effects of some piperazine alkanol derivatives
Özet
Purpose: the aim of this study was to investigate probable antinociceptive activities of some piperazine alkanol derivatives in some nociceptive tests. Materials and Methods: Potential antinociceptive activities of the piperazine alkanol derivatives (20 mg/kg) against mechanic, thermal and chemical nociceptive stimuli were evaluated by tail-clip, hot-plate, acetic acid-induced writhing, and formalin tests. Rota-Rod test was performed to evaluate probable effect of the test compounds on motor coordination of mice. Results: Morphine used as a reference drug exhibited analgesic effect in tail-clip, hot-plate, acetic acid-induced writhing, and formalin tests, as expected. 2-(4-substituted-piperazin-1-yl)-1-phenylpropan-1-ol compounds, which carry 2-hydroxyethyl (C3), phenyl (C6), 4-methylphenyl (C7), 4-chlorophenyl (C8), 4-fluorophenyl (C9), 4nitrophenyl (C10) and benzhydryl (C11) substituents, increased the reaction time of mice against mechanic and thermal nociceptive stimuli in tail-clip and hot-plate tests, respectively. the same test compounds decreased chemical stimulus-induced nociceptive response in acetic acid-induced writhing and formalin tests. Antinociceptive effects of the compounds C7, C8, and C11 were found to be statistically more significant than the compounds C3, C6, C9, and C10. Naloxone, non-selective opioid receptor antagonist (5 mg/kg), totally antagonized the antinociceptive effect observed in all of the nociceptive tests. Conclusion: These findings revealed antinociceptive activity of the compounds C3, C6-C11, and pointed out that this effect was associated with both central and peripheral mechanisms. in addition, naloxone antagonism indicated the involvement of opioid mechanisms in the activity.
