Evaluation of carvedilol-loaded Eudragit®nanoparticles
Özet
The objective of present study was to prepare positively charged carvedilol-loaded nanoparticles providing a controlled release formulationby spray dryer techniqueand wasto examine the effect of different derivative of Eudragit®polymers on entrapment efficiency (EE%), dissolution profile andrelease kinetics. Two non-biodegradable positively charged polymers, Eudragit®RS100 and RL100 were used alone or in combination. The prepared formulations were evaluated for theirparticle size, polydispersity index, zeta potential,in vitrodissolution and in vitrorelease kinetics study.Particle sizes of placebo nanoparticlesand carvedilolloaded nanoparticles were 418.2±18.5/ 402.3±22.0/416.3±12.5 and 535.5±13.8/ 529.4±10.2/ 530.4±10.4 nm, respectively with PDI valuesof approximately 0.4–0.6 for each. Carvedilol loading was resulted in positive electrical charge on nanoparticles. The drug encapsulation efficiency was 68.45±4.67/ 63.58±2.30/ 65.67±4.21.In vitrocumulative release from the nanoparticles was 80-90 % at 48 hour.Morphology and solid state analyzes were performed also in nanoparticles. The results of this research indicate that spray dryer technique is suitable for carvedilol loaded Eudragit®nanoparticles and no burst effect but a prolonged drug release was observed from formulations.
