Yazar "Altıntop, Mehlika Dilek" için listeleme
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Antifungal Effects of Some Oxadiazole Derivatives on Pathogenic Molds
Bazı oksadiazol türevleri Aspergillus parasiticus, Aspergillus flavus, Aspergillus niger, Fusarium solani, Fusarium moniliforme and Stachybotrys chartarum 'a karşı in vitro olarak test edilmiştir. Butün bileşikler en yüksek ... -
Antifungal effects of some oxadiazole derivatives on pathogenic molds [Bazi{dotless} oksadiazol türevlerinin patojenik küfler üzerindeki antifungal etkileri]
Some oxadiazole derivatives were tested in vitro against Aspergillus parasiticus, Aspergillus flavus, Aspergillus niger, Fusarium solani, Fusarium moniliforme and Stachybotrys chartarum. All compounds showed the highest ... -
Antifungal, mosquito deterrent, and larvicidal activity of N-(benzylidene)-3-cyclohexylpropionic acid hydrazide derivatives
Tabanca, Nurhayat; Wedge, David E.; Ali, Abbas; Khan, Ikhlas A.; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek (Springer Birkhauser, 2013)Hydrazone derivatives possess good antifungal and insecticidal activities and their structures are used in pesticide design. In the present study, for the first time, ten hydrazone derivatives (1-10) were evaluated for ... -
Apoptotic effects of some carbazole derivatives on lung carcinoma and glioma cell lines
Çiftçi, Gülsen Akalın; Temel, Halide Edip; Yıldırım, Şafak Ulusoylar; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Genç, Lütfi (Springer Birkhauser, 2013)In this study, we aimed to study the apoptotic effects of 2-[(9-ethyl-9H-carbazol-3-yl)amino]-2-oxoethyl N,N-disubstituted dithiocarbamates on A549 lung carcinoma and C6 glioma cell lines. Cytotoxicity analyses of DNA ... -
Bazı yeni tiyazolin türevlerinin sentezleri ve antimikrobiyal etkilerinin araştırılması
Altıntop, Mehlika Dilek (Anadolu Üniversitesi, 2012)Medisinal kimyada, antimikrobiyal ilaç tasarlama ve geliştirme çalışmalarında, hidrazon yapısı taşıyan tiyazolin türevi bileşikler büyük önem kazanmıştır. Bu çalışmada, hidrazon yapısı taşıyan yeni tiyazolin türevleri ... -
Bazı yeni triazol türevlerinin sentezleri ve antifungal etkilerinin araştırılması
Altıntop, Mehlika Dilek (Anadolu Üniversitesi, 2009)Sistemik fungal enfeksiyonlar, immün sistemi baskılanmış hastalarda önemli morbidite ve mortalite nedenidir. Son yirmi yılda özellikle Candida türlerine bağlı olarak bu tür fungal enfeksiyonların görülme sıklığı önemli ... -
Biological evaluation of a series of benzothiazole derivatives as mosquitocidal agents
Sever, Belgin; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Tabanca, Nurhayat; Estep, Alden S.; Becnel, James J.; Bloomquist, Jeffrey R. (Sciendo, 2019)Aedes aegypti is associated with the transmission of numerous human and animal diseases, such as yellow fever, dengue fever, chikungunya, and more recently Zika virus. Emerging insecticide resistance has created a need to ... -
A Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells
Çiftçi, Gülsen Akalın; Sever, Belgin; Altıntop, Mehlika Dilek (Turkish Pharmacists Assoc, 2019)Objectives: Akt is considered as an attractive target for anticancer drug discovery and development and therefore extensive efforts have been devoted to the discovery of new potent anticancer agents targeting Akt. Materials ... -
Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives
Çiftçi, Gülsen Akalın; Altıntop, Mehlika Dilek; Temel, Halide Edip; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2017)Background: Cancer is one of the leading causes of morbidity and mortality worldwide and extensive efforts have been devoted to the discovery of new anticancer agents. In the last few decades, the clinical efficacy of ... -
Design, synthesis and biological evaluation of new bis(thiosemicarbazone) derivatives as potential targeted anticancer agents for non-small cell lung cancer
Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı; 0000-0003-4847-9711; 0000-0001-5098-8967; 0000-0003-0280-5550; 0000-0002-8159-663X; Sever, Belgin; Akalın Çiftçi, Gülşen; Özdemir, Ahmet; Altıntop, Mehlika Dilek (2020)Thiosemicarbazonesrepresent an important class of ligandsfortargeted therapyof many types of cancer including non-small celllung cancer. In order to identify potential antitumoragentsfor targeted therapy oflung cancer, new ... -
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors
Sever, Belgin; Altıntop, Mehlika Dilek; Radwan, M. O.; Özdemir, Ahmet; Otsuka, Masami; Fujita, M.; Çiftçi, H. I. (Elsevier Masson SAS, 2019)Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or prognostic markers in tumor progression. Based on ... -
Design, synthesis and in vitro COX inhibitory profiles of a new series of tetrazole-based hydrazones
Anadolu Üniversitesi, Eczacılık Fakültesi; Altıntop, Mehlika Dilek; Sever, Belgin; Temel, Halide Edip; Kaplancıklı, Zafer Asım; Özdemir, Ahmet (Anadolu Üniversitesi, 2022)Inhibition of cyclooxygenases (COXs), by selective and nonselective inhibitors, is a favorable approach for pharmacologic intervention in a variety of disorders such as cancer. For this purpose, a new class of tetrazole-hydrazone ... -
Design, synthesis and in vitro evaluation of new thiosemicarbazone derivatives as potential anticancer agents
Sever, Belgin; Çiftçi, Gülsen Akalın; Özdemir, Ahmet; Altıntop, Mehlika Dilek (Marmara University, 2019)Thiosemicarbazones play a pivotal role as potential therapeutic agents for the management of lung cancer. 4-(4-Cyanophenyl)-1-[(5-arylfuran-2-yl)methylene]thiosemicarbazides (1-10) were obtained via the reaction of ... -
Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety
Altıntop, Mehlika Dilek; Çiftçi, Halil İbrahim; Radwan, Mohamed O.; Sever, Belgin; Kaplancıklı, Zafer Asım; Ali, Taha F. S.; Özdemir, Ahmet (MDPI, 2018)In an attempt to develop potent antitumor agents, new 1,3,4-thiadiazole derivatives were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the K562 chronic myelogenous ... -
Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Çiftçi, Gülsen Akalın; Özdemir, Ahmet (MDPI, 2018)In an attempt to develop potent anticancer agents targeting Akt, new thiazole derivatives (1-10) were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma, and NIH/3T3 ... -
Design, Synthesis, and Neuroprotective Effects of a Series of Pyrazolines against 6-Hydroxydopamine-Induced Oxidative Stress
Özdemir, Ahmet; Sever, Belgin; Altıntop, Mehlika Dilek; Tilki, Elif Kaya; Dikmen, Miriş (MDPI, 2018)Parkinson's disease (PD) is a chronic, progressive, and age-related neurodegenerative disorder characterized by the loss of midbrain dopaminergic neurons caused by the accumulation of free radicals and oxidative stress. ... -
Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Çiftçi, Gülsen Akalın; Turan, Gülhan; Kaplancıklı, Zafer Asım; Özdemir, Ahmet (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)In the current work, new 1,3,4-oxadiazole derivatives were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cell lines. Compounds ... -
Design, synthesis, in vitro and in silico evaluation of new pyrrole derivatives as monoamine oxidase inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Osmaniye, Derya; Sağlık, Begüm Nurpelin, Begüm N.; Özdemir, Ahmet (Wiley-V C H Verlag GMBH, 2018)In an effort to develop potent monoamine oxidase (MAO) inhibitors, new pyrrole derivatives were obtained via the selective reduction of the CC bonds of 1-(1-methyl-1H-pyrrol-2-yl)-3-[5-(aryl)furan-2-yl]prop-2-en-1-ones ... -
Eskişehir'de Eczane Teknisyenleri üzerine Bir Araştırma
Bu çalışmada, Eskişehir'deki eczacıların bakış açısından eczane teknisyenlerinin değerlendirilmesi üzerine bir araştırma gerçekleştirilmesi amaçlanmıştır. Metod: Bu çalışmanın eczacıları tesadüfî örnekleme yöntemi ile ... -
Eskişehir'de Vitamin Kullanım Alışkanlıkları Üzerine Dar Kapsamlı Bir Araştırma
Bu çalışmada, Eskişehir'de dört farklı sosyo-kültürel grubu temsil eden 500 kişinin vitamin kullanım alışkanlıkları ve bu alışkanlıkları etkileyen faktörler çalışılmıştır. Araştırmaya katılan denekler tesadüfi örnekleme ...
