Yazar "Can, Özgür Devrim" için listeleme
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1,3,5-triaril-4,5-dihidro-1h-pirazol türevi bazı bileşiklerin benzodiazepin reseptörleri aracılıklı anksiyolitik-benzeri etkileri
Can, Özgür Devrim; Turan, Nazlı; Alyu, Feyza (2016)Amaç: Pirazol, üç karbon atomundan ve yan yana iki azot atomundan oluşan beş üyeli heterosiklik bir halka sistemidir. Literatürde pirazol çekirdeği taşıyan kimyasal bileşiklerin santral sinir sistemi üzerinde önemli bir ... -
2-, 3- ve 4-metilfenoksiasetik asid ile karvakrol asetat'ın düz kaslar üzerindeki etkisi
Can, Özgür Devrim (Anadolu Üniversitesi, 2002)Bu çalışmada, 2-, 3-, 4-metilfenoksiasetik asid ve karvakrol asetat maddelerinin izole sıçan düz kaslarında asetilkolin (ACh) ve KCl ile oluşturulan kasılmalar üzerindeki farmakolojik etkileri araştırılmıştır. İzole organlar ... -
Acetylcholinesterase Inhibitory Effects of Some Benzothiazole-Piperazine Derivatives
Demir Özkay, Ümide; Can, Özgür Devrim; Özkay, Yusuf (Elsevier Science BV, 2011)… -
Agomelatin'in antinosiseptif etkinliğinin deneysel akut ağrı modelleri ile araştırılması
Kasap, Merve (Anadolu Üniversitesi, 2015)Agomelatin, melatoninin MT? ve MT? reseptörlerine agonist ve serotoninin 5-HT?c reseptörlerine antagonist etki gösteren, kendine has etki mekanizmasına sahip yeni bir antidepresan ilaçtır. Bu tez çalışmasında agomelatin'in ... -
Agomelatinin antihiperaljezik ve antiallodinik etkilerinin deneysel diyabetik nöropati modeli ile araştırılması
Aydın, Taliha Harika (Anadolu Üniversitesi, 2015)Bu tez çalışmasında, agomelatin'in streptozotosin (STZ) ile diyabet oluşturulmuş sıçanlarda gelişen hiperaljezi ve allodini üzerine terapötik etkinliği çeşitli deneysel ağrı metotları ile araştırılmıştır. Agomelatin'in ... -
Analgesic activity of Hawthorn seed extract
Can, Özgür Devrim; Özkay, Ümide Demir; Nilgün, Öztürk; Öztürk, Yusuf (Acta Pharmacologica Sinica, 2006)… -
Analgesic and antispasmodic activities of 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid: Evidence for the importance of the 2-(o-substituted phenyl) group
Aydın, Süleyman; Arslan, Rana; Can, Özgür Devrim (2003)Benzimidazole 5-carboxylic acid derivatives were investigated for analgesic activity in this study. Of the benzimidazole compounds tested, 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid showed remarkable naloxone ... -
Analgesic and antispasmodic activities of 2-(2-nitro-phenyl)-1H-benzimidazole 5-carboxylic acid: evidence for the importance of the 2-(o-substituted phenyl) group
Aydın, Süleyman; Arslan, Rana; Can, Özgür Devrim (Govi-Verlag GMBH, 2003)Benzimidazole 5-carboxylic acid derivatives were investigated for analgesic activity in this study. Of the benzimidazole compounds tested, 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid showed remarkable naloxone ... -
Anti-depressant-like effect of vitexin in BALB/c mice and evidence for the involvement of monoaminergic mechanisms
Can, Özgür Devrim; Özkay, Ümide Demir; Ucel, Umut İrfan (Elsevier Science BV, 2013)The present study was designed to investigate the putative effect of vitexin, a flavone C-glucoside present in some drugs, medicinal plants and nutraceuticals, on the central nervous system. Vitexin (10-30 mg/kg) did not ... -
Anti-nociceptive effect of vitexin mediated by the opioid system in mice
Özkay, Ümide Demir; Can, Özgür Devrim (Pergamon-Elsevier Science LTD, 2013)In the present study, we determined the potential anti-nociceptive activity of vitexin, a C-glycosylated flavone, by conducting some acute nociceptive tests in mice. Centrally mediated anti-nociceptive effect was evaluated ... -
Anticholinesterase activity screening of some novel dithiocarbamate derivatives including piperidine and piperazine moieties
Levent, Serkan; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Can, Özgür Devrim; Özkay, Ümide Demir; Uçucu, Ümit (Taylor & Francis LTD, 2017)The present study was undertaken to synthesize some novel lipophilic piperazine and piperidinedithiocarbamates and investigate their inhibitory potencies against cholinesterase enzymes. In the synthetic studies, 44 new ... -
Antidepressant-like effect of gallic acid in mice: Dual involvement of serotonergic and catecholaminergic systems
Can, Özgür Devrim; Turan, Nazlı; Özkay, Ümide Demir; Öztürk, Yusuf (Pergamon-Elsevier Science LTD, 2017)Aims: This study was planned to examine the antidepressant potency of gallic acid (30 and 60 mg/kg), a phenolic acid widely distributed in nature, together with its possible underlying monoaminergic mechanisms. Main methods: ... -
Antihyperalgesic Activity of Atomoxetine on Diabetes-Induced Neuropathic Pain: Contribution of Noradrenergic and Dopaminergic Systems
Barbaros, Mustafa Burak; Can, Özgür Devrim; Ucel, Umut İrfan; Yücel, Nazlı Turan; Özkay, Ümide Demir (MDPI, 2018)Atomoxetine is a selective noradrenaline reuptake inhibitor drug. Based on the knowledge that agents increasing monoamine levels in the central nervous system have therapeutic potential for neuropathic pain, it is planned ... -
Antihyperalgesic and antiallodynic effects of mianserin on diabetic neuropathic pain: A study on mechanism of action
Ucel, Umut İrfan; Can, Özgür Devrim; Özkay, Ümide Demir; Öztürk, Yusuf (Elsevier Science BV, 2015)This study used various experimental pain methods to investigate the effects of subacute mianserin administration on diabetes-induced neuropathic pain in rats. The effect of mianserin on hyperalgesia occurring in connection ... -
Antinociceptive Activities of Some 4,5-Dihydro-1H-Pyrazole Derivatives: Involvement of Central and Peripheral Pathways
Can, Özgür Devrim; Alyu, Feyza; Turan, Nazlı; Özdemir, Ahmet (Bentham Science Publ LTD, 2016)This study was planned to investigate possible antinociceptive activity of 1,5-diaryl-3-[4-(methylsulfonyl) phenyl]-4,5-dihydro-1H-pyrazole derivatives (2a-s), based on the analgesia-inducing potential of 4,5-dihydro-1H-pyrazole ... -
Antinociceptive activities of some triazole and pyrazoline moieties-bearing compounds
Özkay, Ümide Demir; Can, Özgür Devrim; Kaplancıklı, Zafer Asım (Springer Birkhauser, 2012)This study was designed to evaluate the potential antinociceptive activities of some triazole-pyrazoline derivatives. All of the test compounds (100 mg/kg) increased the reaction times of mice in hotplate and tail-clip ... -
Atomoksetin'in streptozotosin ile diyabet oluşturulmuş sıçanlarda gelişen hiperaljezi üzerine etkilerinin araştırılması
Can, Özgür Devrim; Anadolu Üniversitesi, Sağlık Bilimleri Enstitüsü, Farmakoloji Anabilim Dalı; Babaros, Mustafa Burak (Tez (yüksek lisans) - Anadolu Üniversitesi, 2018)Selektif noradrenalin geri alım inhibitörü bir ilaç olan atomoksetin, dikkat eksikliği hiperaktivite bozukluğunun tedavisinde endikedir. Beyinde monoamin konsantrasyonunu artırıcı etki gösteren ilaçların nöropatik ağrı ... -
Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion
Bektur, Ezgi; Şahin, Erhan; Ceyhan, Emre; Dönmez, Dilek Burukoğlu; Canbek, Mediha; Baycu, Cengiz; Can, Özgür Devrim (Taylor & Francis LTD, 2019)Objectives: Neuropathic pain reduces the life qualities of patients with Diabetes mellitus. Clinical guidelines recommend relief in diabetic neuropathic pain through the use of some antidepressants, anticonvulsants, opioids ... -
A benzothiazole/piperazine derivative with acetylcholinesterase inhibitory activity: Improvement in streptozotocin-induced cognitive deficits in rats
Özkay, Ümide Demir; Can, Özgür Devrim; Sağlık, Begüm Nurpelin; Turan, Nazlı (Polish Acad Sciences Inst Pharmacology, 2017)Background: Acetylcholinesterase (AChE) inhibitors are frequently prescribed to mitigate the cognitive decline in Alzheimer's disease. Thus, we investigated the possible efficacy of the AChE inhibitor 2-[(6-Nitro-2-benzothiazolyl) ...
