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Toplam kayıt 15, listelenen: 1-10
Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer's Disease
(MDPI, 2018)
Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the ...
Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains
(Scientific Technical Research Council Turkey-Tubitak, 2014)
Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a-j) were confirmed by ...
Synthesis and anticancer activity of some bisquinoxaline derivatives
(2011)
Mevcut antikanser ajanlara karşı rezistans gelişimi, yeni antikanser ajanlar için bir araştırma alanı yaratmaktadır. Bununla birlikte, normal hücreler üzerinde etki göstermeden ya da en az etkiyle anormal hücrelerin ...
Yeni piperazin bileşiklerinin sentezi ve antikolinesteraz etkilerinin araştırılması
(2017)
Amaç: Bu çalışmada bazı yeni piperazin bileşiklerinin antikolinesteraz amaçlanmıştır. Gereç ve Yöntem: On yeni piperazin türevi sentezlenmiştir. Sentezlenen bileşiklerin yapı aydınlatmaları spektroskopik yöntemler ile ...
Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates
(Bentham Science Publ LTD, 2017)
In the present study, nineteen new fluoro-benzimidazole derivatives, including nifuroxazide analogs, were synthesized by microwave-supported reactions and tested against a panel of pathogenic microorganisms consisting of ...
Synthesis and Evaluation of N-[1-(((3,4-Diphenylthiazol-2(3H)-ylidene)amino)methyl)cyclopentyl]acetamide Derivatives for the Treatment of Diseases Belonging to MAOs
(Hindawi LTD, 2018)
A series of N-[1-(((3,4-diphenylthiazol-2(3H)-ylidene)amino)methyl)cyclopentyl]acetamide derivatives (4a-4i) were synthesized in good yield and assayed for their inhibitory potency against monoamine oxidase (MAO) isoforms. ...
Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives
(MDPI, 2019)
Alzheimer's disease (AD), one of the main causes of aged dementia, is a progressive and degenerative neurological disorder characterized by loss of cognition and memory. Although the symptomatic treatment of AD, particularly ...
Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
(MDPI, 2018)
During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal that various substitutions at ...
Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives
(Hindawi LTD, 2016)
Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N'-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide ...
Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives
(Hindawi LTD, 2014)
18 novel dithiocarbamate derivatives were synthesized in order to investigate their inhibitory potency on acetylcholinesterase enzyme and antimicrobial activity. Structures of the synthesized compounds were elucidated by ...