Güncel Gönderiler: Farmasötik Toksikoloji Anabilim Dalı
Toplam kayıt 46, listelenen: 21-40
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Citalopram Induces Reproductive Toxicity in Male Rats
(Wiley, 2017)Background: Citalopram hydrobromide (CTL) has been shown to cause sexual dysfunction; however, its reproductive toxicity potential has not been sufficiently elucidated in men. Therefore, we aimed to clarify the toxic effects ... -
Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.
(Hindawi Publishing Corporation, 2013)The fruit of Physalis peruviana L. (PPL) has been traditionally used as antispasmodic, diuretic, antiseptic, sedative, and analgesic all over the world. We aimed to perform qualitative content analysis of the fruits of PPL ... -
Is N-acetyl cysteine protective against monocrotaline-induced toxicity?
(Taylor & Francis Inc, 2013)Monocrotaline (MCT) is a pyrrolizidine alkaloid which induces cardio-pulmonary toxicity and hepatotoxicity in animals and humans. MCT is frequently ingested because of food grain contamination accidentally or in the form ... -
Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms
(Taylor & Francis LTD, 2015)Ciprofloxacin (CPX) is a fluoroquinolone antibiotic used for treating respiratory, urinary tract, gastrointestinal and abdominal infections. There are only a limited number of studies related to neurological adverse effects ... -
Insulin Neuropathy: Rare Adverse Effect of Insulin Therapy
(Ibn Sina Trust, 2016)Insulin neuropathy is a rare adverse effect of insulin therapy in patients with long-term uncontrolled hyperglycemia. Neuropathic pain appears after the correction of blood glucose level. A 34 years old woman with severe ... -
Determination of Phenolic Compounds of Stachys Rupestris Montbret Et Aucher Ex Bentham By Lc-Ms/Ms and Its Biological Activities
(Parlar Scientific Publications (PSP), 2018)One of the largest genus of Lamiaceae, Stachys, extended from south western part of Asia to America, represented in Turkey with % 48 endemism rate. In this presented study LC-ESI-MS/MS properties, anticandidal, antioxidant ... -
Evaluation of antimicrobial, Cytotoxic and genotoxic activities of Ganoderma lucidum (Reishi mushroom)
(University Karachi, 2017)Ganoderma lucidum (GL) is a mushroom used as a traditional remedy for the treatment of various infections since ancient times. This study, was aimed to investigate antimicrobial activity potential of GL against Staphylococcus ... -
Assessment of the Endothelial Functions in Monocrotaline-induced Pulmonary Hypertension
(Taylor & Francis Inc, 2013)Pulmonary hypertension (PH) is a life-threatening disease that causes endothelial dysfunction in the pulmonary vascular bed. Systemic endothelial dysfunction has also been reported in PH. This study compared the systemic ... -
Effects of Everolimus in Combination with Sildenafil in Monocrotaline-induced Pulmonary Hypertension in Rats
(Humana Press Inc, 2012)In our study, we investigated the efficacy of everolimus in combination with sildenafil on hemodynamic and morphological parameters in rats with monocrotaline-induced pulmonary hypertension (PH). Right ventricular pressure ... -
Biotransformation of abietic acid by fungi and biological evaluation of its metabolites
(Elsevier Sci LTD, 2017)Biotransformation of abietic acid was carried out initially using 28 different microbial strains. Among the evaluated, Mucor ramannianus produced a known metabolite namely 2 alpha-hydroxy-dehydroabietic acid whereas ... -
Synthesis and MAO inhibitory activity of novel thiazole-hydrazones
(Scientific Technical Research Council Turkey-Tubitak, 2017)A series of new thiazole-hydrazones (3a-3n) were synthesized, characterized, and screened for their hMAO-A and hMAO-B inhibitory activity by an in vitro fluorometric method. Selectivity indexes (SIs) were expressed as IC50 ... -
Reproductive toxicity after levetiracetam administration in male rats: Evidence for role of hormonal status and oxidative stress
(Public Library Science, 2017)Levetiracetam (LEV) is an antiepileptic drug commonly used in the treatment of epilepsy because of its excellent safety profile in all age groups. It is remarkable that there are no studies evaluating the toxic effects of ... -
The effects of gender difference on monocrotaline-induced pulmonary hypertension in rats
(SAGE Publications LTD, 2013)The present study aimed to compare the effect of gender difference on hemodynamic consequences in the development of monocrotaline (MCT)-induced pulmonary hypertension in rat. The effect of antioxidant enzyme systems on ... -
Evaluation of the reproductive toxicity of levetiracetam in male rats
(Elsevier Ireland LTD, 2016)… -
Evaluation of hepatotoxicity associated with citalopram administration in rats
(Elsevier Ireland LTD, 2015)… -
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPAR gamma Agonists and their Antidiabetic Effects on Type 2 Diabetes
(Nature Publishing Group, 2017)Peroxisome proliferator-activated receptor gamma (PPAR gamma) has received significant attention as a key regulator of glucose and lipid homeostasis. In this study, we synthesized and tested a library of novel 5-benzylid ... -
Sertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms
(Wolters Kluwer Medknow Publications, 2017)This study was conducted to clarify the toxic effects of sertraline (SRT) on the reproductive system of male rats and to elucidate the underlying mechanisms. Rats were treated orally with SRT at doses of 5, 10, and 20 mg ... -
Matrix metalloproteinases are possible targets in monocrotaline-induced pulmonary hypertension: investigation of anti-remodeling effects of alagebrium and everolimus
(Turkish Soc Cardiology, 2017)Objective: In our study, sildenafil alone and everolimus or alagebrium in combination with sildenafil were investigated in terms of their additional therapeutic and anti-remodeling activity in monocrotaline-induced pulmonary ...
