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dc.contributor.authorÖztürk, Ahmet Alper
dc.contributor.authorGüven, Umay Merve
dc.contributor.authorYenilmez, Evrim
dc.contributor.authorŞenel, Behiye
dc.date.accessioned2019-10-19T16:02:39Z
dc.date.available2019-10-19T16:02:39Z
dc.date.issued2018
dc.identifier.issn0326-2383
dc.identifier.urihttps://hdl.handle.net/11421/13854
dc.descriptionWOS: 000449335700012en_US
dc.description.abstractThe purpose of the present investigation was to design and compare the release characteristics of sustained-release formulations of Flurbiprofen (FLB) loaded nanoparticles (NPs) by using spray-dryer technique using Eudragit RLPO (RLPO), Eudragit RSPO (RSPO) and RLPO:RSPO 1:1 ratio. NPs Formulation were prepared by spray-dryer. Structures of nanoparticles were characterized by entrapment efficiency (EE%), dissolution study and release kinetic study with the DDSolver software program, particle size (PS), zeta potential, morphology, DSC, XRD, FTIR and H-1-NMR analyses. Cytotoxicity studies were performed on the NIH/3T3 mouse embryonic fibroblast cells. FLB-loaded NPs demonstrated nanostructural character while in vitro release study showed extended release of FLB-incorporated. The PS of the prepared FLB-NPs was affected by the polymer type and was in the range of 532 and 565 nm. Entrapment efficiency (EE %) varied from 70 to 76%, depending upon the polymer difference to drug ratio. According to the DDSolver criterion used to evaluate release kinetics, Korsmeyer-Peppas model were determined to be the most appropriate kinetic models for NPs. The results obtained in cell viability study indicate a dose and time dependent decrease in viability of NIH/3T3 for FLB and FLB-NPs. As a conclusion of this study; the effect of the polymer type on the PS, EE% and release properties of NPs has been examined and discussed in detail. According to results FLB-NPs seem to be a promising extended release drug delivery system for oral administration.en_US
dc.language.isoengen_US
dc.publisherColegio Farmaceuticos Provincia De Buenos Airesen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDdsolveren_US
dc.subjectEudragit Rlpoen_US
dc.subjectEudragit Rspoen_US
dc.subjectFlurbiprofenen_US
dc.subjectNanomedicineen_US
dc.subjectSustained Releaseen_US
dc.titleEffects of Different Derivatives of Eudragit Polymer on Entrapment Efficiency, In Vitro Dissolution, Release Kinetics and Cell Viability Results on Extended Release Flurbiprofen Loaded Nanomedicinesen_US
dc.typearticleen_US
dc.relation.journalLatin American Journal of Pharmacyen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalıen_US
dc.identifier.volume37en_US
dc.identifier.issue10en_US
dc.identifier.startpage1981en_US
dc.identifier.endpage1992en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.contributor.institutionauthorŞenel, Behiye


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