Browsing Makale Koleksiyonu by Author "Sivas, Hülya"
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Biological activities of Cu(II) and Hg(II) complexes of a heptadentate Schiff base ligand
Ergene, Emel; Sivas, Hülya; Benkli, Kadriye (Tubitak Scientific & Technical Research Council Turkey, 2010)Two metal complexes were synthesized as [Hg(L)](ClO4)(2) and [Cu(L)](ClO4), by the template reaction between 2,6-bis(2-aminothiophenoxymethyl)pyridine and 2,2'-bipyridine-6,6'-dicarboxaldehyde in the presence of Hg(II) and ... -
Biological assays on the effects of Acra3 peptide from Turkish scorpion Androctonus crassicauda venom on a mouse brain tumor cell line (BC3H1) and production of specific monoclonal antibodies
Çalışkan, Figen; Ergene, Emel; Sögüt, İbrahim; Hatipoğlu, İbrahim; Basalp, Aynur; Sivas, Hülya; Kanbak, Güngör (Pergamon-Elsevier Science LTD, 2013)Constitutes of the venom scorpion are a rich source of low molecular mass peptides which are toxic to various organisms, including man. Androctonus crassicauda is one of the scorpions from the Southeastern Anatolia of ... -
Composition, antimicrobial activity and in vitro cytotoxicity of essential oil from Cinnamomum zeylanicum Blume (Lauraceae)
Ünlü, Mehmet; Ergene, Emel; Ünlü, Gülhan Vardar; Sivas, Hülya; Vural, Nilüfer (Pergamon-Elsevier Science LTD, 2010)The essential oil from the bark of Cinnamomum zeylanicum Blume was analyzed by GC-MS and bioassays were carried out. Nine constituents representing 99.24% of the oil were identified by GC-MS. The major compounds in the oil ... -
Cytosolic $Ca^{2+}$ levels in CO25 myoblast cells bearing a human N-ras oncogene after stimulation by thapsigargin and growth factors
Zeytinoğlu, Hülya; Gıbson, Ian (1999)CO25 miyoblast hücrelerinin, thapsigargin (ThG), bombesin ve epidermal büyüme faktörü (EGF) ile stimülasyonları sonucunda hücre içi kalsiyum [$Ca^{2+}$ ]i seviyeleri araştırılmıştır. ThG, çoğunlukla hücre içi kalsiyum ... -
Cytotoxicity of Plumbagin, Rapanone and 12 other naturally occurring Quinones from Kenyan Flora towards human carcinoma cells
Kuete, Victor; Omosa, Leonidah K.; Tala, Viviane R. Sipowo; Midiwo, Jacob O.; Mbaveng, Armelle T.; Swaleh, Sauda; Sivas, Hülya (Bmc, 2016)Background: Cancer is a major public health concern globally and chemotherapy remains the principal mode of the treatment of various malignant diseases. Methods: This study was designed to investigate the cytotoxicity of ... -
Cytotoxicity of seputhecarpan D, thonningiol and 12 other phytochemicals from African flora towards human carcinoma cells
Kuete, Victor; Ngnintedo, Dominique; Fotso, Ghislain W.; Karaosmanoğlu, Oğuzhan; Ngadjui, Bonaventure T.; Keumedjio, Felix; Sivas, Hülya (Bmc, 2018)Background: Despite the remarkable progress in cancer therapy in recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one of the most effective ... -
Cytotoxicity of the methanol extracts of Elephantopus mollis, Kalanchoe crenata and 4 other Cameroonian medicinal plants towards human carcinoma cells
Kuete, Victor; Fokou, Fabrice W.; Karaosmanoğlu, Oğuzhan; Beng, Veronique P.; Sivas, Hülya (Bmc, 2017)Background: Cancer still constitutes one of the major health concerns globally, causing serious threats on patients, their families, and the healthcare system. Methods: In this study, the cytotoxicity of the methanol extract ... -
Determination of genotoxic, antigenotoxic and cytotoxic potential of the extract from lichen Cetraria aculeata (Schreb.) Fr. in vitro
Sivas, Hülya; Seller, Zerrin; Tüylü, Berrin; Türk, A. O.; Barutca, B. (Wiley, 2008)Naturally occurring compounds can have protective effects towards mutagens and carcinogens as shown by numerous studies. In the present study, the genotoxic/antigenotoxic activities of the extract from lichen Cetraria ... -
The effects of n-ras oncogene expression on PDGF-BB stimulated responses in cultured mouse myoblasts
Sivas, Hülya; Griffiths, S. L.; Dawson, A. P.; Gibson, I. (1995)The role of the ras oncogene in the signalling pathway triggered by platelet-derived growth factor BB (PDGF-BB) has been investigated in a cell line which normally differentiates into myotubes. Following the activation of ... -
The effects of parasitism by the ectoparasitoid Bracon hebetor Say (Hymenoptera: Braconidae) on host hemolymph proteins in the Mediterranean flour moth Ephestia kuehniella Zeller (Lepidoptera: Pyralidae)
Altuntaş, Hülya; Kılıç, Ali Yavuz; Sivas, Hülya (Tubitak Scientific & Technical Research Council Turkey, 2010)Parasitism of lepidopteran larvae by braconid wasps has significant effects on host hemolymph proteins and the physiology of the host insect. In this study the post-parasitism effect's of a gregarious idiobiont ectoparasitoid ... -
Genotoxicity and antigenotoxicity of Origanum oil and carvacrol evaluated by Ames Salmonella/microsomal test
İpek, E; Sivas, Hülya; Okay, S; Tüylü, Berrin; Kürkçüoğlu, Mine; Başer, K. Hüsnü Can (Elsevier Sci LTD, 2005)This study evaluates the genotoxic and antigenotoxic effects of the essential oil of Origanum onites L. and carvacrol that are used in medicine, flavouring of food and crop protection by Ames Salmonella/microsomal test. ... -
Identification of biomarkers associated with partial epithelial to mesenchymal transition in the secretome of slug over-expressing hepatocellular carcinoma cells
Karaosmanoğlu, Oğuzhan; Banerjee, Sreeparna; Sivas, Hülya (Springer, 2018)Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Complete epithelial to mesenchymal transition (EMT) has long been considered as a crucial step for metastasis initiation. It ... -
In vitro cytotoxicity of compounds isolated from Desbordesia glaucescens against human carcinoma cell lines
Kuete, Victor; Mafodong, F. L. Dongmo; Çelik, I.; Fobofou, S. A. T.; Ndontsa, B. L.; Karaosmanoğlu, Oğuzhan; Sivas, Hülya (Elsevier Science BV, 2017)Malignancies constitute a global health concern and chemotherapy remains the main mode of treatment. The present study was designed to evaluate the cytotoxicity of 8 compounds from Desbordesia glaucescens namely ... -
Inhibition of DNA synthesis by carvacrol in mouse myoblast cells bearing a human N-RAS oncogene
Sivas, Hülya; Seller, Zerrin; Başer, K. Hüsnü Can (Urban & Fischer Verlag, 2003)Monoterpenes are dietary components found in the essential oils of a wide variety of plants. A number of these monoterpenes have antitumor activity. We have investigated the effects of carvacrol obtained by fractional ... -
Investigation of cytogenetic effects of 2, 4, 5 triphenyl imidazole by rat bone marrow micronucleus test
Sivas, Hülya; Saleh, K.; Canbek, M. (2001)The cytogenetic effects of 2, 4, 5 triphenyl imidazole on the micronucleus formation were investigated in rats. Increasing doses of the substance were injected i.p. into Wistar rats and polychromatic and normochromatic ... -
Investigation of genotoxic effects of paraben in cultured human lymphocytes
Bayulken, Devrim Güzel; Tüylü, Berrin; Sinan, Handan; Sivas, Hülya (Taylor & Francis LTD, 2019)Paraben is a phenolic derivative of benzoic acid extensively used as preservatives in food, pharmaceutical, and cosmetic industries due to its antimicrobial characteristics. The objective of this study was to evaluate the ... -
Mutagenicity assay in Salmonella for thirteen 2-substituted-1H-phenanthro (9,10-d) imidazoles
Sivas, Hülya; Ergene, E; Tüylü, Berrin (Taylor & Francis LTD, 2003)Some 2-substituted-1H-phenanthro [9,10-d] imidazole compounds synthesized as a predrugs were tested in mutagenicity assays in Salmonella strains TA97, TA98, and TA100 using a plate incorporation assay both with and without ... -
Niclosamide Suppresses Proliferation, Induces Apoptosis and Inhibits Wnt/beta-catenin Signaling Pathway in Human Ovarian Cancer Cells
Gündoğdu, Ayşe Çakır; Kaplanoğlu, gülnur Take; Sivas, Hülya; Varol, Reyhan; Seymen, Cemile Merve (Gazi University, Fac Med, 2019)Objective: The aim of this study is to investigate in vitro effects of an antihelminthic drug niclosamide on human ovarian carcinoma cell line OVCAR3. Methods: MTT assay was applied to investigate the cytotoxic effects of ... -
A Preliminary Study for the Detection of Gelatinolytic Proteases from the Scorpion Androctonus crassicauda (Turkish Black Scorpion) Venom
Çalışkan, Figen; Sivas, Hülya; Şahin, Yalçın (Walter De Gruyter GMBH, 2009)Objectives: Despite the long history on proteolytic activity studies, no study has been reported about the presence of proteases from the Turkish scorpion A. crassicauda venom which is among the most toxic species in the ... -
Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells
Demiroğlu-Zergeroğlu, Asuman; Ergene, Emel; Ayvali, Nurettin; Kuete, Victor; Sivas, Hülya (Bmc, 2016)Background: Malignant mesothelioma is a locally aggressive and highly lethal neoplasm of pleural, peritoneal and pericardial mesothelial cells without successful therapy. Previously, we reported that Quercetin in combination ...