Yazar "Sivas, Hülya" için Fen Fakültesi listeleme
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Inhibition of DNA synthesis by carvacrol in mouse myoblast cells bearing a human N-RAS oncogene
Sivas, Hülya; Seller, Zerrin; Başer, K. Hüsnü Can (Urban & Fischer Verlag, 2003)Monoterpenes are dietary components found in the essential oils of a wide variety of plants. A number of these monoterpenes have antitumor activity. We have investigated the effects of carvacrol obtained by fractional ... -
Investigation of cytogenetic effects of 2, 4, 5 triphenyl imidazole by rat bone marrow micronucleus test
Sivas, Hülya; Saleh, K.; Canbek, M. (2001)The cytogenetic effects of 2, 4, 5 triphenyl imidazole on the micronucleus formation were investigated in rats. Increasing doses of the substance were injected i.p. into Wistar rats and polychromatic and normochromatic ... -
Investigation of genotoxic effects of paraben in cultured human lymphocytes
Bayulken, Devrim Güzel; Tüylü, Berrin; Sinan, Handan; Sivas, Hülya (Taylor & Francis LTD, 2019)Paraben is a phenolic derivative of benzoic acid extensively used as preservatives in food, pharmaceutical, and cosmetic industries due to its antimicrobial characteristics. The objective of this study was to evaluate the ... -
Mutagenicity assay in Salmonella for thirteen 2-substituted-1H-phenanthro (9,10-d) imidazoles
Sivas, Hülya; Ergene, E; Tüylü, Berrin (Taylor & Francis LTD, 2003)Some 2-substituted-1H-phenanthro [9,10-d] imidazole compounds synthesized as a predrugs were tested in mutagenicity assays in Salmonella strains TA97, TA98, and TA100 using a plate incorporation assay both with and without ... -
Niclosamide Suppresses Proliferation, Induces Apoptosis and Inhibits Wnt/beta-catenin Signaling Pathway in Human Ovarian Cancer Cells
Gündoğdu, Ayşe Çakır; Kaplanoğlu, gülnur Take; Sivas, Hülya; Varol, Reyhan; Seymen, Cemile Merve (Gazi University, Fac Med, 2019)Objective: The aim of this study is to investigate in vitro effects of an antihelminthic drug niclosamide on human ovarian carcinoma cell line OVCAR3. Methods: MTT assay was applied to investigate the cytotoxic effects of ... -
Novel Nanoimaging Approach: Antibodious Polymeric Nanolabel for Intracellular Alpha-Fetoprotein Targeted Monitoring
Ünlüer, Özlem Biçen; Ersöz, Arzu; Say, Rıdvan; Tomsuk, Özlem; Sivas, Hülya (Wiley-Blackwell, 2013)This study describes preparation and use of novel labeled and antibodious polymeric nanolabels (anti-alpha fetoprotein cross-linked nanolabels) as an immunogenic and semisynthetic nanolabel with potential prognostic and ... -
A Preliminary Study for the Detection of Gelatinolytic Proteases from the Scorpion Androctonus crassicauda (Turkish Black Scorpion) Venom
Çalışkan, Figen; Sivas, Hülya; Şahin, Yalçın (Walter De Gruyter GMBH, 2009)Objectives: Despite the long history on proteolytic activity studies, no study has been reported about the presence of proteases from the Turkish scorpion A. crassicauda venom which is among the most toxic species in the ... -
Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells
Demiroğlu-Zergeroğlu, Asuman; Ergene, Emel; Ayvali, Nurettin; Kuete, Victor; Sivas, Hülya (Bmc, 2016)Background: Malignant mesothelioma is a locally aggressive and highly lethal neoplasm of pleural, peritoneal and pericardial mesothelial cells without successful therapy. Previously, we reported that Quercetin in combination ... -
Stimulation of dendritic cells with vaccine and vaccine-antibody complex and effect on immune response
Hatipoğlu, İbrahim; Sögüt, İbrahim; Ercan, Duygu; Aksu, SÖner; Sivas, Hülya; Basalp, Aynur (Tubitak Scientific & Technical Research Council Turkey, 2013)Dendritic cell (DC) vaccines are a promising and potent therapeutic tool for chronic diseases, autoimmune diseases, and cancer because of the unique ability of DCs to stimulate T cells. The challenge of DC vaccines is to ... -
Stimulation of dendritic cells with vaccine and vaccine–antibody complex and effect on immune response
Dendritic cell (DC) vaccines are a promising and potent therapeutic tool for chronic diseases, autoimmune diseases, and cancer because of the unique ability of DCs to stimulate T cells. The challenge of DC vaccines is to ... -
Synhesis and genotoxic activities of five 2-aryl-substituted-benzothiazole derivatives
Sivas, Hülya; Meryc, Asiye; Tüylü, Berrin; Ergene, Emel (Chiminform Data S A, 2006)Five 2-aryl-substituted-benzothiazoles were synthesized from o-amino-thiophenol and their structural assignments were made by H-1-NMR. Mutagenicily of derivatives was tested by Salmonella microsome assay using TA98 and ... -
Synthesis and mutagenicity of 2-aryl-substitute (o-hydroxy-, m-bromo-, o-methoxy-, o-nitro-phenyl or 4-pyridyl) benzothiazole derivatives on Salmonella typhimurium and human lymphocytes exposed in vitro
Tüylü, Berrin Ayaz; Sivas, Hülya; Işıkdağ, İlhan (Springer, 2007)Derivatives of 2-aryl-substitute (o-hydroxy-, m-bromo-, o-methoxy-, o-nitro-phenyl or 4-pyridyl) benzothiazole were synthesized and tested for their mutagenicity in in vitro assays: (i) in the Ames test with Salmonella ...